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Ozempic, which has a lower dose of 0.5-2 semaglutide, is FDA-approved for diabetes control, while higher-dose semaglutide, Wegovy, is approved for weight loss

These injections are typically administered by healthcare professionals to treat vitamin B12 deficiency in people with pernicious anemia and other conditions, but some clinics offer training for safe self-injection at home

Keywords: Chronic spontaneous urticaria, GLP-1 receptor agonists, Semaglutide, Tirzepatide, Immunomodulation, Metabolic inflammation Key Summary Points Introduction Chronic spontaneous urticaria (CSU) is characterized by mast cell degranulation leading to the recurrent appearance of wheals lasting for more than 6 weeks