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Loss of Cathepsin D leads to lysosomal dysfunction and the accumulation of various cellular proteins associated with neurodegenerative diseases

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial

Some of this is driven by cost and access problems

320 In addition to muscular manifestations, Duchenne muscular dystrophy is often associated with psychosocial abnormalities and cognitive impairment, while histopathologically neuronal death and dendritic abnormalities are frequently observed post-mortem