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Reduced Muscle Cramps and Spasms: Magnesium can help relax muscle tension and reduce the frequency and severity of muscle cramps and spasms

(2009), in a proteomic analysis of the CSF of PD patients and controls, found significantly higher CSF levels of apolipoprotein E, autotoxin, and some SOD1 isoforms, and lower levels of complement C 4 when compared with controls, while Pigment epithelium-derived factor (PEDF or serpin F1) was not significantly increased, and complement C 3 and haptoglobin were similar in PD patients and controls

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A systematic review of 41 loneliness studies (over 16,000 participants), in which different brain imaging technologies were used, showed altered structure and/or function in the medial and dorsolateral prefrontal cortex, anterior insula, amygdala, hippocampus, and posterior and superior temporal cortex [75]