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3 to 7 days Clearer thinking, steadier mood, more stamina 2 to 4 weeks Steadier energy and more consistent day-to-day benefits 2 to 3 months+ Longer-term support for nerve function and steady Why a Shot Works Faster Than Oral Supplements When you swallow a B12 pill, it has to travel through your stomach and small intestine and rely on a protein called intrinsic factor to be absorbed

Alternative Therapies in Health and Medicine , 27 (4), 813

Alternatively, if the vial has positive pressure, pushing water in becomes difficult because you are compressing the air inside

Once you find the dose that is not creating these problems, over time your body may adjust to it and you won't have such a strong reaction