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Warnings: Patients with early Leber's disease (hereditary optic nerve atrophy) may experience severe and rapid optic atrophy when treated with vitamin B12. Additionally, treating severe megaloblastic anemia with vitamin B12 can lead to fatal hypokalemia due to increased erythrocyte potassium requirements

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Handling must only be performed by qualified and trained laboratory professionals in accordance with applicable regulations and institutional guidelines

They operate on different cell types, through different receptor systems, affecting different physiological processes