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Hatch, A

Last, we analyzed the potential market access dynamics that will complicate pricing for a therapy in this space given the lack of marketed analogs and uncertainty over the clinical relevance of surrogate endpoints

Evid-based Complement Altern Med 10:4287890

Additional evidence that metformin protects mitochondrial function has been provided by Wang et al., reported that treatment of streptozotocin (STZ)-induced diabetic mice with metformin (300 mg/kg/day) in their drinking water for 4 weeks suppressed mitochondrial fission through inhibition of dynamin-related protein (Drp1) via an AMPK-dependent process and enhanced mitochondrial fusion (186)