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For example, 2-propyl-2-pentenoic acid (2-en-VPA), a byproduct of -oxidation, and 2-propyl-4-pentenoic acid (4-en-VPA), a byproduct of -oxidation, have been incriminated in the development of cerebral oedema and in the hepatotoxicity of VPA, respectively [1724]

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Table 1 Kinetic parameters in the reduced model

Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies