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Additionally, intravascular hemolysis results in renal injury, which develops as a consequence of filtering hemoproteins released from hemolytic red cells by the kidneys [229]

Without adequate carnitine levels, that process slows

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This stimulatory effect occurs through multiple mechanisms, including increased COL1A1 and COL1A2 gene transcription, enhanced procollagen mRNA stability, and improved post-translational processing of procollagen molecules