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Metformin remains the first-line pharmacological approach to the treatment of T2DM, along with lifestyle modification, with the exception of cases where metformin is not tolerated or contraindicated

The coding sequence of the SmGST gene was cloned into the prokaryotic expression vector pQE-80L, and BL21 bacteria harboring the recombinant plasmid pQE-80L-SmGST expressed a soluble fusion protein

The study also opens the door for more future research about the administration routes of vitamin B12 and other vitamins