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These impacts include anti-inflammatory effects, reduced amyloid-beta (A) deposition, reduced tau protein hyperphosphorylation, and improved insulin signaling ( 2 GLP-1R in AD GLP-1R plays a key role in AD

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In murine models of inflammatory arthritis, liraglutide treatment significantly reduced synovial inflammation, joint damage, and the expression of cytokines such as TNF- and IL-1, likely mediated through GLP-1R expressed on macrophages and fibroblast-like synoviocytes within the inflamed joint microenvironment [368,369,370]

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