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Anyone with a history of pancreatitis, severe gastrointestinal disease, or significant kidney impairment should raise these conditions with a clinician before any GLP-1 evaluation

In addition, a meta-analysis of 1193 patients with baseline SGLT2i use in AMPLITUDE-O and Harmony Outcomes revealed an HR for MACE of 0.78 (95% CI 0.491.24) with SGLT2is and 0.77 (95% CI 0.680.87) without SGLT2is ( P -value for interaction 0.95), and an HR for HHF of 0.34 (95% CI 0.120.96) with SGLT2is and 0.72 (95% CI 0.550.92) without SGLT2is ( P -value for interaction 0.18) [48]

N Engl J Med 349:941948 Beak SA, Small CJ, Ilovaiskaia I, Hurley JD, Ghatei MA, Bloom SR, Smith DM (1996) Glucagon-like peptide-1 (GLP-1) releases thyrotropin (TSH): characterization of binding sites for GLP-1 on -TSH cells

Inflamm Bowel Dis (2007) 13(9):115364.10.1002/ibd.20174 13 HelanderHFFandriksL