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The vitamin is also essential for DNA synthesis and red blood cell formation, meaning deficiency can have wide-ranging effects beyond the nervous system, including fatigue and cognitive difficulties

Inflammatory bowel syndrome, intestinal lymphomas, vomiting or diarrhea are reported to cause problems in cobalamin absorption

This condition requires lifelong intramuscular vitamin B12 therapy to prevent serious neurological complications

Neuropeptide Y (NPY) Inhibitors The ARC NPY neurons inhibit the anorexigenic POMC neurons (via NPY Y1 and Y5 receptors) and promote the release of the orexigenic neuropeptides orexin and MCH in the LHA, thus promoting food intake