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Group 1: Placebo Group 2 (Low-dose): Phentermine 7.5mg plus Topiramate 46mg once daily Group 3 (High-dose): Phentermine 15mg plus Topiramate 92mg once daily All participants were monitored for a little over 1 year (56 weeks) and were also provided with some lifestyle counselling that included a LEARN manual (I am not actually sure what this means

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FIGURE 13 4 Discussions Over the years following its discovery, GLP-1 has garnered significant attention for its incretin effect on glucoregulation in the management of T2DM, including its role in improving cardiovascular, respiratory, and renal functions (Singh et al., 2025b)