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MDD and sickness behavior Vegetative symptoms of melancholic depression, such as anorexia, weight loss, psychomotor retardation, sleep disorders, and anergy, are substantially and positively correlated with signs of the AP response, including increased serum haptoglobin levels and the alpha 2 globulin fraction [28, 110]

Methods Study design and data source This large, population-based, retrospective cohort study was conducted using the TriNetX research network (Cambridge, MA, USA)

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