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doi: 10.1016/j.cmet.2017.04.013 69 MoreiraGAzevedoFRibeiroLSantosAGuadagniniDGamaPet al

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For decades, KRAS was regarded as one of the most challenging targets in oncology due to its high affinity for GTP/GDP and the lack of suitable binding pockets

Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity