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Because there were potential reproductive abnormalities observed in preclinical toxicity studies in Sprague Dawley rats and cynomolgus monkeys (see Supplementary Results for complete details of these preclinical studies), out of an abundance of caution, we restricted female subjects to postmenopausal women of nonchildbearing potential

When they become damaged or inefficient, they can hinder the growth of new tissue

"Actually, it involves more work than many were doing even before because now we're sending them to the gym to pick up the dumbbells, to count their protein, to be accountable and do the body composition

Because this approach works by enhancing normal physiology rather than strong receptor activation, the effects tend to be more modest, vary from person to person and depend more heavily on diet and lifestyle