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...which increases insulin synthesis/release and suppresses glucagon production in a glucose-dependent manner Muscle Pancreas b cells a cells Insulin Glucagon Incretin enhancement can indirectly result in glucose uptake in peripheral tissues and a decrease in hepatic glucose production Liver Glucose GLP-1 (glucagon-like peptide-1) DPP-4 (dipeptidyl peptidase-4) JANUVIA GIP (glucose-dependent insulinotropic peptide) Important Information JANUVIA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus