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Postgrad Med (1988) 84(5):21722, 227, 230

The specific response depends on the nature and severity of the side effect, but general principles guide appropriate action

With breach of the blood-brain barrier, immune cells infiltration as well as extravasation of blood-borne molecules such as fibronectin triggers, together with the death of oligodendrocytes, degeneration and transection of axons and starts a multicellular inflammatory response associated with reactive astro- and microgliosis