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Methylated flavonoids as anti-seizure agents: naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models

Another LRRK2 inhibitor NEU-411 is currently investigated in a phase 2 trial (NEULARK, NCT06680830, see Table 5) 5.3 Targeting -Synuclein Pathology Based on the robust evidence for a central role of intraneuronal misfolding, oligomerization and aggregation of -synuclein as well as cell-to-cell transmission of pathological -synuclein species these mechanisms have become key targets for drug development programmes focused on disease modification in PD

4e) and higher accumulation of mitochondrial mass, probably due to prevention of ROS-induced organellar damage (Fig

Rijken et al., 2011)