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Monosodium urate (MSU) crystals deposited in synovial tissue can interact with the innate immune system, triggering an inflammatory response that results in typical symptoms of gout, including pain, swelling, and redness [7]

Moreover, early studies on HIV-1-infected subjects associated GSH deficiency with a poor lymphocytic response and impaired survival following HIV-1 infections 28,29,30 , implying a role for GSH in disease