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Additionally, GLP-1 RAs with established CV benefitsspecifically liraglutide, subcutaneous semaglutide, dulaglutide, and efpeglenatideare recommended for patients with T2DM and ASCVD to reduce CV events, regardless of baseline or target HbA1c levels or concurrent glucose-lowering therapy (Class I, LoE A)
Neuroscience 162, 972979
FDA guidance recommends regular follow-up visits or telehealth check-ins, particularly during the first 12 weeks when gastrointestinal side effects are most common and dose adjustments may be needed
These established therapies have decades of clinical trial data demonstrating efficacy in reducing disease activity, preventing structural damage, and improving quality of life
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