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Nicosia N, Kwiecie I, Mazurek J, Mika K, Bednarski M, Miceli N, et al

The GCGR arm adds pathways tirzepatide lacks: hepatic fatty-acid oxidation (~85–90% liver fat reduction in Phase 2a MASLD), adipose lipolysis, and thermogenic energy expenditure

if more than 2 consecutive doses are missed, they should restart at a lower dose and follow the dose escalation schedule