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At the end of the study, each animal had received each of the six different treatments selected for comparison

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Further flow cytometry analysis confirmed that caloric restriction modulates the PI3K/AKT/c-Myc signaling axis and reduces granulocyte-macrophage colony-stimulating factor (GM-CSF) production in Th17 cells, thereby promoting CD4 + T cell balance (127)

De forma caracterstica, este efecto se atena al ir disminuyendo progresivamente los niveles de glucosa circulante, lo que condiciona una reduccin de los niveles de insulina y una restauracin de la secrecin del glucagn, con lo que se aleja la posibilidad de una hipoglucemia