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Spoorthy MS, Chakrabarti S, Grover S

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17 While ERAD was previously thought to be associated with PQC, which safeguards protein maturation, recent studies have demonstrated that ERAD also regulates the abundance of folding-competent proteins as a means to fine-tune key physiological processes, suggesting that ERAD constitutively functions to ensure both protein fidelity and abundance

33 , 53 , 56 , 57 Mechanisms of loss of function of MC1R red hair colour variants include reduced receptor functional activity and reduced cell surface expression of the receptor