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Some GLP-1 medicines are available as oral tablets, but only for diabetes treatment

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Tirzepatide Once Weekly for the Treatment of Obesity New England Journal of Medicine 387(3) 2022PMID: 35658024 NEJM 7 Sumithran P, Prendergast LA, Delbridge E, et al

This coordinated engagement across the pancreas, brain, gut, liver, and adipose tissue underlies the mechanistic rationale for dual GLP-1/GIP receptor agonists, and explains why they have been described as super GLP-1RAs, reflecting genuine potentiation of GLP-1 action by GIP receptor agonist co-activation