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Description

AOD-9604 works by activating beta-3 adrenergic receptors that are highly expressed in adipose (fat) tissue but have minimal presence in appetite-regulating brain regions

Hanai T, Shiraki M, Ohnishi S, et al

Additionally, administration of recombinant IL-22 to high-fat diet (HFD)-fed mice decreased hepatic fat accumulation and downregulated the expression of lipogenic genes, including PPAR, PPAR, and SREBP-1c (130) ( Figure 6A )