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2.4 Metabolicreproductive psychological axis: multifaceted pathways of GLP-1RA action Building on Figure 1B, we discuss four non-mutually exclusive routes by which GLP-1RAs may contribute to reproductive improvement in PCOS: (i) metabolic mediation, (ii) central neuroendocrine modulation, (iii) attenuation of lipotoxicity/inflammation, and (iv) psychological and behavioral facilitation

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CLOCK and BMAL1/ARNTL disruption is implicated in inflammation, mitochondrial dysfunction, dopamine, and serotonin disturbance in BD patients [36, 168], as well as in iron dysregulation [169]

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