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GnatkovskyVLibrizziLTrombinFde CurtisM

The persistent inflammatory environment not only exacerbates oxidative stress but also promotes the recruitment and activation of additional immune cells, further perpetuating the autoimmune response [58]

To address these limitations, a variety of nanodelivery systemsincluding polymeric nanoparticles, lipid-based carriers, and nanofibershave been developed to enhance the solubility, stability, and targeted delivery of CUR

However, CoA does not fit well within the modeled catalytic pocket, consistent with our experimental findings that ABHD11 does not hydrolyze the glutaryl-CoA thioester