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According to the invention, an ionic liquid Linker is introduced on a conventional solid phase carrier, and then the Linker is sequentially connected with corresponding amino acids in a semaglutide sequence through a solid phase synthesis method, and the semaglutide protamine is obtained through cracking and purification

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Levels of NLRP3, caspase-1, and IL-1 in granulosa cells of DOR patients (Navarro-Pando et al., 2021)