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Research published in a 2025 narrative review found that GLP-1 medications can lead to muscle loss, micronutrient deficiencies, and digestive disruptions if nutritional needs aren't actively managed

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semaglutide users in both countries as well as oral semaglutide users in Italy mostly received guideline-recommended starting dosage formulations at first dispensation and either required the maintenance dosage formulations of 0.5 mg and 7.0 mg, respectively, or an increase to higher dosage formulations of 1.0 mg and 14.0 mg, respectively, within a year