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Patients should be counseled to report severe abdominal pain (potential pancreatitis), right upper quadrant pain (possible gallbladder disease), visual changes (especially with diabetic retinopathy), persistent nausea or vomiting, or signs of dehydration which may increase risk of acute kidney injury

Participants who received semaglutide had greater reductions in the number of heavy drinking days (41% fewer, on average) compared to those receiving placebo (26%.) The amount of alcohol consumed over the prior 30 days dropped by over 70% in the semaglutide group (from 78 ounces of 100% alcohol at baselinethe equivalent of 130 shots of 80-proof spirits over 30 daysto 23 ounces, or about 39 shots)

Patients experiencing social stigma related to their weight or medication use might also find relief through cannabis

Semaglutide degrades when exposed to heat