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Different stress conditions, including energy depletion, oxidative stress, and hyperosmolarity which emerge in many diseases and some genetic disorders, lead to shortening the erythrocyte lifespan thus facilitating the removal of the damaged and defective erythrocytes [134]

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Mediation analysis confirmed that reduction in inflammatory biomarkers was a contributing pathway to cardiovascular protection

Proc Natl Acad Sci USA 109:1199311998 Wu G, Fang Y-Z, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health