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Upregulated DRP1 in kidney diseases can promote the permeability of OMM via the interaction with Bcl-2-associated X protein (BAX), a crucial executor of mitochondria-regulated apoptosis (Spitz and Gavathiotis, 2022) to trigger cell apoptosis (Qin et al., 2019)

Also the TAM receptor Mertk 52 and the damage-associated molecular pattern Hmgb1 53 , were downregulated in CD38- relative to IgG-injected 5xFAD mice (Fig