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1 A review article of multiple randomized controlled trials reports an average weight loss of around 16% among users, with some losing as much as 17.4%

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(For small-molecule drugs like semaglutide, at least seven years must have passed from its FDA approval date to be eligible for selection, and for drugs with multiple FDA approvals, CMS will use the earliest approval date to make this determination.) If that happens, a negotiated Medicare price would be available beginning in 2027

The study's limitations include that it was conducted within the Veterans Affairs health system, which serves a population that is mostly older, white and male, although Al-Aly said the results were consistent in more than 35,000 women