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Research indicates that the co-existence of PCOS and MASLD increases the likelihood of developing type 2 diabetes, cardiovascular disease, and chronic kidney disease, which are more serious and difficult to manage than MASLD alone (Shahbaz et al., 2022)

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Apigenin (10, 30 M) modulates IL-31 expression and release in stimulated human mast cells, with reductions in MAPK and NF-B p65 phosphorylation activation evident by suppression of JNK, ERK, and p38 activation, and expression of PKC, IB kinase (IKK), and IB [134]