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Lower tCho at 3 months was significantly associated with higher somatic symptoms at 3 months (B = 5.02, p = 0.003, r = 0.216, Fig
Pregnant patients or those planning pregnancy should not use either medication, though the reasoning differs (Metformin for potential effects on fetal development, Retatrutide due to insufficient safety data)
MTX-related nephrotoxicity has been attributed to oxidative and inflammatory stress, mitochondrial dysfunction, and apoptosis [2, 13]
In the SELECT trial, semaglutide reduced major adverse cardiovascular events in patients with overweight or obesity and established atherosclerotic cardiovascular disease without diabetes [16]
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