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This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Ninth Peoples Hospital, affiliated with Shanghai Jiao Tong University School of Medicine

These can include: Nausea Diarrhea or constipation Abdominal discomfort Heartburn For most people, these symptoms are mild to moderate and tend to subside as the body becomes accustomed to the medication

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In endomyocardial biopsies, higher burdens of mtDNA mutations are associated with reduced ejection fraction and worse outcomes ( 3.3 Oxidative stress and calcium overload Oxidative stress and calcium overload are tightly interconnected mechanisms of mitochondrial dysfunction in HF