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In drug-induced pyridoxine deficiency, such as in patients taking isoniazid, a higher replacement dose is often used, for example, 100 mg IV or IM daily for 3 weeks, to rapidly correct the deficiency, followed by a maintenance dose of around 30 mg daily

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In people with confirmed B12 deficiency, supplementation is required, with the choice of formulation, duration and dosage dependent on the underlying cause and severity of the deficiency and patient preference

People receiving high-dose B12 therapy appear more likely to experience skin changes than those taking standard dietary supplements, based on case reports