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2021 May 24;9(5):e3540, Parashar S, Venkataram A

Additionally, while some studies indicate that TGF1 inhibits proliferation and promotes differentiation 141,144 , other research suggests that TGF1 signaling enhances cellular proliferation in the crypt under irradiation 138

All IGF-1 derivatives play prominent roles in cell division, cell proliferation, and cell-to-cell communication

However, Maiorino and co-workers recently redefined the catalytic motif of GPx1 as tetrad by establishing through mutagenesis study in Drosophila model that asparagine (Asn or N) residue was also essential for the catalytic activity of GPx1 [13]