MDA is linked to the Lys residues of proteins and enzymes, and forms Schiff bases, for phospholipids, nucleic acids (shown mutagenic properties), and also MDA inhibits a number of thiol dependent enzymes: glucose-6-phosphatase, Na + -K + -ATP-ase, Ca ++ -ATP-ase
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The body is forced to switch to inefficient, anaerobic (oxygen-free) energy production, which generates lactic acid and further exacerbates systemic pain and fatigue
and Scherag, H.A.: Agreement with the disulfide stretching frequency-conformation correlation of Sugeta, Go, and Miyazawa