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If low-molecular weight HA is produced in excessive amounts or cannot be cleared promptly an uncontrolled inflammatory response develops, which aggravates tissue damage

Although the value of Vd does not confirm penetration of a drug into specific tissues, in general the higher the value of the Vd, the more likely it is that the drug will reach sequestered sites such as the brain and cerebrospinal fluid, the prostate and other sex organs, the eye, and the mammary gland

The diagnosis usually involves the following: clinical findings, the finding of 5-oxoprolinuria, low levels of glutathione, low activity of glutathione synthetase, and mutation analysis of the glutathione synthetase gene

Her hands and feet were short and broad, with increased palmar wrinkling ( Figure 1a , b , c )