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These compounds contain an aromatic ring with a phenolic group and can exist in cis and trans isomers due to the presence of a double bond adjacent to the phenolic group

VGF (non-acronymic), a neurosecretory presynaptic protein, is consistently downregulated in AD brain and cerebrospinal fluid (CSF), and increased VGF expression is associated with better cognitive outcomes in AD 6,10,11,12,13,14,15

NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway

Measurement of APAP and its major metabolites Separations were performed on a 2.6 m Kinetex XB-C18 column (50 2.1 mm ID) obtained from Phenomenex (Macclesfield, UK), at a temperature of 40 C and a flow-rate of 0.5 mL min 1