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The number of replicates per comparison represents biological replicates, with technical replicates within biological replicates averaged before statistical testing unless indicated

When sex emerged as a significant factor, separate ANOVAs were performed for males and females

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To assess how the availability of glucagon-like peptide-1 receptor agonists (GLP-1RAs) has shifted clinical approaches to obesity management within that population, researchers analyzed records from more than 204,000 13- to 25-year-olds treated for obesity between May 2022 and January 2026 in Epic Cosmos, a U.S.-based electronic health record database