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However, despite these advantages, the clinical use of native GLP-1 is significantly limited by its short plasma half-life (12 min), owing to rapid enzymatic degradation by DPP-4 and renal clearance

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S2 Kinetics of formation (t= 0, 0.5, 2, 6, 24 and 48h) of APAP metabolites in HRG cells and Hepatocytes after exposure to APAP and APAP-Cys, including a zoom of metabolites showing low intensity signals