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Principal component 3

When administered by intravenous (IV) injections, the QMP-engineered albumin variant lacking L585 demonstrated enhanced cellular recycling and extended plasma half-life in transgenic mice expressing human FcRn, comparable to that of full-length QMP

It is important to recognise that type 2 diabetes itself is a risk factor for cognitive impairment and dementia

TGR5 and bile acid TGR5 is a member of the G-protein-coupled receptor superfamily and is expressed in various tissues, including pancreas Cells, endocrine cells in the small intestine, thyroid, brown adipose tissue, cardiomyocytes, and macrophages [11, 13]