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This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid hydroperoxides and electrophiles

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Synergistic pathways allow lower tretinoin levels for equal efficacy while niacinamide buffers irritation and azelaic acid targets pigment, simplifying regimens and improving adherence

[DOI] [PubMed] [Google Scholar] Sturgeon X, Gardiner KJ