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GLP-1 medications have gained attention for their ability to support weight loss, especially for individuals who have had difficulty losing weight with traditional diet and exercise changes

A separate strategy involves co-packaging -cells with GLP-1-loaded NPs within alginate hydrogels, which significantly improved cellular metabolism and resulted in an 8-fold increase in insulin secretion [130]

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Therefore, the changes in the gut microbiota after a single injection of GLP-1RA seem to reflect the original effects of GLP-1RA more clearly than the changes in the gut microbiota after chronic administration