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Therefore, to investigate the influence of GST enzyme activity on busulfan metabolism, the empirical model developed was used as a base, with a dedicated compartment incorporated to dynamically quantify the relative amount of GSH available over time, based on theoretical mechanisms, as reported by Langenhorst et al

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Increased adiposity, which plays a central role in both aging and obesity-related pathologies, is responsible for enhanced oxidative stress and chronic low-grade inflammatory responses by promoting free radical production and the release of pro-inflammatory cytokines

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