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Esposito and colleagues hypothesized that their higher levels of pyruvate may not lead to larger benefit due to pyruvate's U-shaped dose-response curve (Esposito et al., 2007)

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independent replication remains limited

As the core effector molecule of this pathway, GPX4 is a unique selenoprotein and the only member of the GPX family capable of directly catalyzing the reduction of membrane phospholipid hydroperoxides (30)