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As the implanted tumour cells lack p53 expression (ID8 Trp53 / ), and p21 is a p53-dependent gene, we wanted to confirm that (a subset of) the p21-positive cells were tumour derived

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Grandi V, Milanesi N, Sessa M, Gola M, Cappugi P, Pimpinelli N.G Ital Dermatol Venereol

Given the reduced levels of activated HGF and cMet in hepsin / mice, combined with the increased abundance of GJs, we hypothesize that these mice may be more vulnerable to oxidative stress, potentially exacerbating the severity of APAP-induced liver injury